Membrane-type matrix metalloproteinase-1 (MT1-MMP) gene is overexpressed in highly invasive hepatocellular carcinomas
T Harada, S Arii, M Mise, T Imamura, H Higashitsuji… - Journal of …, 1998 - Elsevier
Background/Aims: The matrix metalloproteinase (MMP) family play important roles in the
invasion of cancer cells by degrading the extracellular matrices. The current study was
designed to determine the expression pattern of membrane-type matrix metalloproteinase-1
(MT1-MMP) in hepatocellular carcinomas and its participation in invasion potential.
Methods: MT1-MMP mRNA expression was examined in 25 human hepatocellular
carcinoma specimens using Northern blot, and the correlation to clinico-pathological …
invasion of cancer cells by degrading the extracellular matrices. The current study was
designed to determine the expression pattern of membrane-type matrix metalloproteinase-1
(MT1-MMP) in hepatocellular carcinomas and its participation in invasion potential.
Methods: MT1-MMP mRNA expression was examined in 25 human hepatocellular
carcinoma specimens using Northern blot, and the correlation to clinico-pathological …