Complete structure of the mouse mast cell receptor for IgE (Fc ϵ RI) and surface expression of chimeric receptors (rat-mouse-human) on transfected cells
C Ra, MH Jouvin, JP Kinet - Journal of Biological Chemistry, 1989 - ASBMB
The high affinity receptor for IgE (Fc ϵ RI) found on mast cells and basophils is a tetrameric
complex of a single α subunit, a single β subunit, and two identical γ subunits. The genes for
the three subunits of mouse Fc ϵ RI have now been cloned from the mast cell line, PT18.
When compared at the DNA level, the rat and mouse subunits are similarly conserved.
However, at the protein level the homology between mouse and rat α is surprisingly low
(71% identities) especially in the cytoplasmic regions (57% identities) which are of different …
complex of a single α subunit, a single β subunit, and two identical γ subunits. The genes for
the three subunits of mouse Fc ϵ RI have now been cloned from the mast cell line, PT18.
When compared at the DNA level, the rat and mouse subunits are similarly conserved.
However, at the protein level the homology between mouse and rat α is surprisingly low
(71% identities) especially in the cytoplasmic regions (57% identities) which are of different …