Inhibition of human neutrophil function by 6-aminonicotinamide: the role of the hexose monophosphate shunt in cell activation
JG Bender, DE Van Epps - Immunopharmacology, 1985 - Elsevier
Stimulation of polymorphonuclear leukocytes with phorbol myristate acetate (PMA) or
chemotactic factors such as f-Met-Leu-Phe (fMLP) activates a membrane oxidase which
results in the generation of the superoxide anion (O 2−) and the oxidation of NADPH to
NADP+. The subsequent reduction of NADP+ to NADPH is believed to be directly
dependent upon activation of the hexose monophosphate shunt (HMPS). To further
understand the role of the HMPS in the oxidative burst, we examined the kinetics of HMPS …
chemotactic factors such as f-Met-Leu-Phe (fMLP) activates a membrane oxidase which
results in the generation of the superoxide anion (O 2−) and the oxidation of NADPH to
NADP+. The subsequent reduction of NADP+ to NADPH is believed to be directly
dependent upon activation of the hexose monophosphate shunt (HMPS). To further
understand the role of the HMPS in the oxidative burst, we examined the kinetics of HMPS …