Neutrophils in human diseases
HL Malech, JI Gallin - New England Journal of Medicine, 1987 - Mass Medical Soc
HL Malech, JI Gallin
New England Journal of Medicine, 1987•Mass Medical SocHUMAN neutrophilic polymorphonuclear leukocytes (neutrophils) provide an effective host
defense against bacterial and fungal infection, but they are also important in the
pathogenesis of tissue damage in certain noninfectious diseases. Some important events in
neutrophil function that will be discussed in this review are shown in Figure 1. Mild to
moderate abnormalities of neutrophil function have been reported in many acquired and
congenital diseases. 1 2 3 4 5 In most of these disorders, the biochemical or morphologic …
defense against bacterial and fungal infection, but they are also important in the
pathogenesis of tissue damage in certain noninfectious diseases. Some important events in
neutrophil function that will be discussed in this review are shown in Figure 1. Mild to
moderate abnormalities of neutrophil function have been reported in many acquired and
congenital diseases. 1 2 3 4 5 In most of these disorders, the biochemical or morphologic …
HUMAN neutrophilic polymorphonuclear leukocytes (neutrophils) provide an effective host defense against bacterial and fungal infection, but they are also important in the pathogenesis of tissue damage in certain noninfectious diseases. Some important events in neutrophil function that will be discussed in this review are shown in Figure 1.
Mild to moderate abnormalities of neutrophil function have been reported in many acquired and congenital diseases.1 2 3 4 5 In most of these disorders, the biochemical or morphologic basis of the defects is unknown and the relevance of the neutrophil defect to the manifestations of the disease is unclear. In contrast, persons with marked neutropenia6 or . . .
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