[HTML][HTML] The calcitonin receptor stimulates Shc tyrosine phosphorylation and Erk1/2 activation: involvement of Gi, protein kinase C, and calcium
Y Chen, JF Shyu, A Santhanagopal, D Inoue… - Journal of Biological …, 1998 - ASBMB
While it is well established that adenylyl cyclase and phospholipase C-β are two proximal
signal effectors for the calcitonin receptor, the more distal signaling pathways are less well
characterized. G protein-coupled receptors can activate Erk1/2 by G s-, G i-, or G q-
dependent signaling pathways, depending on the specific receptor and cell type examined.
Since the calcitonin receptor can couple to all three of these G proteins, the ability of
calcitonin to activate Erk1/2 was investigated. Calcitonin induced time-and concentration …
signal effectors for the calcitonin receptor, the more distal signaling pathways are less well
characterized. G protein-coupled receptors can activate Erk1/2 by G s-, G i-, or G q-
dependent signaling pathways, depending on the specific receptor and cell type examined.
Since the calcitonin receptor can couple to all three of these G proteins, the ability of
calcitonin to activate Erk1/2 was investigated. Calcitonin induced time-and concentration …
