Angiotensin II stimulation of granuloma macrophage phagocytesis and actin polymerization in murine schistosomiasis mansoni
JV Weinstock, JT Kassab - Cellular immunology, 1984 - Elsevier
In murine Schistosomiasis, components of the renin-angiotensin system are present in
isolated liver granulomas. Furthermore, granuloma macrophages have receptors for
angiotensin II (AII). These observations with other evidence suggest that angiotensins
function in immunoregulation. Since AII can stimulate actin-myosin interactions and since
macrophages have contractile proteins, it was determined whether AII could alter the
phagocytic activity of granuloma macrophages. AII, at concentrations which saturate AII …
isolated liver granulomas. Furthermore, granuloma macrophages have receptors for
angiotensin II (AII). These observations with other evidence suggest that angiotensins
function in immunoregulation. Since AII can stimulate actin-myosin interactions and since
macrophages have contractile proteins, it was determined whether AII could alter the
phagocytic activity of granuloma macrophages. AII, at concentrations which saturate AII …