Effect of blood pressure lowering and antihypertensive drug class on progression of hypertensive kidney disease: results from the AASK trial
ContextHypertension is a leading cause of end-stage renal disease (ESRD) in the United
States, with no known treatment to prevent progressive declines leading to ESRD.
ObjectiveTo compare the effects of 2 levels of blood pressure (BP) control and 3
antihypertensive drug classes on glomerular filtration rate (GFR) decline in hypertension.
DesignRandomized 3× 2 factorial trial with enrollment from February 1995 to September
1998. Setting and ParticipantsA total of 1094 African Americans aged 18 to 70 years with …
States, with no known treatment to prevent progressive declines leading to ESRD.
ObjectiveTo compare the effects of 2 levels of blood pressure (BP) control and 3
antihypertensive drug classes on glomerular filtration rate (GFR) decline in hypertension.
DesignRandomized 3× 2 factorial trial with enrollment from February 1995 to September
1998. Setting and ParticipantsA total of 1094 African Americans aged 18 to 70 years with …