Enteropooling assay: a test for diarrhea produced by prostaglandins
A Robert, JE Nezamis, C Lancaster, AJ Hanchar… - Prostaglandins, 1976 - Elsevier
An assay (enteropooling assay) to test the diarrheogenic property of prostaglandins is
described. Fasted rats are given a prostaglandin either orally or subcutaneously, and are
killed 30 min later. The entire small intestine is removed and its contents collected into a test
tube. The greater the volume of this intestinal fluid, the more diarrheogenic is the
prostaglandin. The assay is simple, rapid, quantitative, and predictive of diarrhea. It can be
used to grade the relative diarrheogenic activity of prostaglandins as well as to test agents …
described. Fasted rats are given a prostaglandin either orally or subcutaneously, and are
killed 30 min later. The entire small intestine is removed and its contents collected into a test
tube. The greater the volume of this intestinal fluid, the more diarrheogenic is the
prostaglandin. The assay is simple, rapid, quantitative, and predictive of diarrhea. It can be
used to grade the relative diarrheogenic activity of prostaglandins as well as to test agents …