Secondary leukemias induced by topoisomerase-targeted drugs
CA Felix - Biochimica et Biophysica Acta (BBA)-Gene Structure …, 1998 - Elsevier
The major established cause of acute myeloid leukemia (AML) in the young is cancer
chemotherapy. There are two forms of treatment-related AML (t-AML). Each form has a de
novo counterpart. Alkylating agents cause t-AML characterized by antecedent
myelodysplasia, a mean latency period of 5–7 years and complete or partial deletion of
chromosome 5 or 7. The risk is related to cumulative alkylating agent dose. Germline NF-1
and p53 gene mutations and the GSTT1 null genotype may increase the risk …
chemotherapy. There are two forms of treatment-related AML (t-AML). Each form has a de
novo counterpart. Alkylating agents cause t-AML characterized by antecedent
myelodysplasia, a mean latency period of 5–7 years and complete or partial deletion of
chromosome 5 or 7. The risk is related to cumulative alkylating agent dose. Germline NF-1
and p53 gene mutations and the GSTT1 null genotype may increase the risk …