Hayflick, his limit, and cellular ageing

JW Shay, WE Wright - Nature reviews Molecular cell biology, 2000 - nature.com
JW Shay, WE Wright
Nature reviews Molecular cell biology, 2000nature.com
Abstract Almost 40 years ago, Leonard Hayflick discovered that cultured normal human cells
have limited capacity to divide, after which they become senescent—a phenomenon now
known as the 'Hayflick limit'. Hayflick's findings were strongly challenged at the time, and
continue to be questioned in a few circles, but his achievements have enabled others to
make considerable progress towards understanding and manipulating the molecular
mechanisms of ageing.
Abstract
Almost 40 years ago, Leonard Hayflick discovered that cultured normal human cells have limited capacity to divide, after which they become senescent — a phenomenon now known as the ‘Hayflick limit’. Hayflick's findings were strongly challenged at the time, and continue to be questioned in a few circles, but his achievements have enabled others to make considerable progress towards understanding and manipulating the molecular mechanisms of ageing.
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