Fibroblast senescence is associated with a loss of proliferative potential and an alteration in
extracellular gene expression. Because the expression of extracellular gene products are
frequently growth state dependent, we undertook a comparative study of the regulation of
the components of the plasminogen activation system in young and senescent cells under
controlled conditions of growth. Young and senescent cells were compared in quiescent and
activated growth conditions for the secretion of tissue-type plasminogen activator (t-PA) …