[HTML][HTML] FcγRIIB1/SHIP-mediated inhibitory signaling in B cells involves lipid rafts

MJ Aman, AC Tosello-Trampont… - Journal of Biological …, 2001 - ASBMB
One type of membrane microdomain, enriched in glycosphingolipids and cholesterol and
referred to as lipid rafts, has been implicated in the generation of activating signals triggered
by a variety of stimuli. Several laboratories, including ours, have recently demonstrated that
the B cell receptor (BCR) inducibly localizes to the rafts upon activation and that functional
lipid rafts are important for BCR-mediated" positive" signaling. In the later phases of the
immune response, coligation of the BCR and the inhibitory receptor FcγRIIB1 leads to potent …