The role of cytokine receptor signaling in lymphocyte development
AM Baird, RM Gerstein, LJ Berg - Current opinion in immunology, 1999 - Elsevier
AM Baird, RM Gerstein, LJ Berg
Current opinion in immunology, 1999•ElsevierCytokine receptor signaling plays an essential role in the early stages of lymphocyte
development. Sials through various cytokine receptors—such as c-kit, flt3/flk2, CXCR4, the
IL-7 receptor and the IL-15 receptor—are known to promote the expansion and survival of
uncommitted progenitor cells as well as their migration to the appropriate microenvironment
and subsequent differentiation into B, T or natural killer cells. The recent generation of mice
deficient in one or more of these signaling pathways has revealed which cytokines play …
development. Sials through various cytokine receptors—such as c-kit, flt3/flk2, CXCR4, the
IL-7 receptor and the IL-15 receptor—are known to promote the expansion and survival of
uncommitted progenitor cells as well as their migration to the appropriate microenvironment
and subsequent differentiation into B, T or natural killer cells. The recent generation of mice
deficient in one or more of these signaling pathways has revealed which cytokines play …
Cytokine receptor signaling plays an essential role in the early stages of lymphocyte development. Sials through various cytokine receptors — such as c-kit, flt3/flk2, CXCR4, the IL-7 receptor and the IL-15 receptor — are known to promote the expansion and survival of uncommitted progenitor cells as well as their migration to the appropriate microenvironment and subsequent differentiation into B, T or natural killer cells. The recent generation of mice deficient in one or more of these signaling pathways has revealed which cytokines play unique and/or redundant roles in each of these lymphocyte lineages during this developmental process.
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