Transforming growth factor-β, basement membrane, and epithelial-mesenchymal transdifferentiation: implications for fibrosis in kidney disease
PJ Stahl, D Felsen - The American journal of pathology, 2001 - ASIP
Interstitial fibrosis is characteristic of many clinical entities including diabetes, ureteral
obstruction, transplant rejection, and glomerulonephritis. 1 The interstitial fibrosis that
accompanies renal disease is a complex process involving derangements in both the
synthesis and degradation of collagen and other extracellular matrix proteins. Cellular
sources of the extracellular matrix laid down during the development of interstitial fibrosis
include fibroblasts and infiltrating macrophages. 1 The fibroblasts may be resident renal …
obstruction, transplant rejection, and glomerulonephritis. 1 The interstitial fibrosis that
accompanies renal disease is a complex process involving derangements in both the
synthesis and degradation of collagen and other extracellular matrix proteins. Cellular
sources of the extracellular matrix laid down during the development of interstitial fibrosis
include fibroblasts and infiltrating macrophages. 1 The fibroblasts may be resident renal …