HLA class I recognition by killer cell Ig-like receptors
EO Long, S Rajagopalan - Seminars in immunology, 2000 - Elsevier
Seminars in immunology, 2000•Elsevier
Copyright 2000 Academic PressNatural killer (NK) cell activation is regulated by a
combination of positive and negative signals coming from repertoires of activating and
inhibitory receptors expressed on the surface of each NK cell. Receptors specific for major
histocompatibility complex (MHC) class I molecules on target cells inhibit NK effector
functions such as cytotoxicity and cytokine production. As reviewed here, the killer cell Ig-like
receptor (KIR) family on human NK cells includes receptors with activating as well as …
combination of positive and negative signals coming from repertoires of activating and
inhibitory receptors expressed on the surface of each NK cell. Receptors specific for major
histocompatibility complex (MHC) class I molecules on target cells inhibit NK effector
functions such as cytotoxicity and cytokine production. As reviewed here, the killer cell Ig-like
receptor (KIR) family on human NK cells includes receptors with activating as well as …
Copyright 2000 Academic PressNatural killer (NK) cell activation is regulated by a combination of positive and negative signals coming from repertoires of activating and inhibitory receptors expressed on the surface of each NK cell. Receptors specific for major histocompatibility complex (MHC) class I molecules on target cells inhibit NK effector functions such as cytotoxicity and cytokine production. As reviewed here, the killer cell Ig-like receptor (KIR) family on human NK cells includes receptors with activating as well as inhibitory potential, receptors that have no known ligand, and inhibitory receptors with well-defined specificities for MHC class I such as HLA-B and HLA-C.
Elsevier