Costimulation in antiviral immunity: differential requirements for CD4+ and CD8+ T cell responses
JK Whitmire, R Ahmed - Current opinion in immunology, 2000 - Elsevier
Current opinion in immunology, 2000•Elsevier
A key step toward improving vaccines is understanding the molecular interactions
responsible for inducing antiviral T cell responses. An emerging theme from recent studies is
that CD4+ and CD8+ T cell responses require distinct costimulatory pathways for activation.
In addition, these costimulatory interactions can play a crucial role during the death phase of
the T cell response and determine the number of effector T cells that survive to become
memory T cells.
responsible for inducing antiviral T cell responses. An emerging theme from recent studies is
that CD4+ and CD8+ T cell responses require distinct costimulatory pathways for activation.
In addition, these costimulatory interactions can play a crucial role during the death phase of
the T cell response and determine the number of effector T cells that survive to become
memory T cells.
A key step toward improving vaccines is understanding the molecular interactions responsible for inducing antiviral T cell responses. An emerging theme from recent studies is that CD4+ and CD8+ T cell responses require distinct costimulatory pathways for activation. In addition, these costimulatory interactions can play a crucial role during the death phase of the T cell response and determine the number of effector T cells that survive to become memory T cells.
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