Mechanisms involved in the evasion of the host defence by Pseudomonas aeruginosa
A Kharazmi - Immunology letters, 1991 - Elsevier
Pseudomonas aeruginosa, an extracellular opportunistic pathogen, utilizes two major
mechanisms to evade the host defence system. One of these mechanisms is the production
of a large number of extracellular products, such as proteases, toxins, and lipases. The two
proteases, alkaline protease and elastase, inhibit the function of the cells of the immune
system (phagocytes, NK cells, T cells), inactivate several cytokines (IL-1, IL-2, IFN-r, TNF),
cleave immunoglobulins and inactivate complement. Inhibition of the local immune …
mechanisms to evade the host defence system. One of these mechanisms is the production
of a large number of extracellular products, such as proteases, toxins, and lipases. The two
proteases, alkaline protease and elastase, inhibit the function of the cells of the immune
system (phagocytes, NK cells, T cells), inactivate several cytokines (IL-1, IL-2, IFN-r, TNF),
cleave immunoglobulins and inactivate complement. Inhibition of the local immune …