[HTML][HTML] The fibrinogen-binding MSCRAMM (clumping factor) of Staphylococcus aureus has a Ca2+-dependent inhibitory site
DP O'Connell, T Nanavaty, D McDevitt… - Journal of Biological …, 1998 - ASBMB
The clumping factor (ClfA) is a cell surface-associated protein of Staphylococcus aureus that
promotes binding of fibrinogen or fibrin to the bacterial cell. Previous studies have shown
that ClfA and the platelet integrin α IIb β 3 recognize the same domain at the extreme C
terminus of the fibrinogen γ-chain. α IIb β 3 interaction with this domain is known to occur in
close proximity to a Ca 2+-binding EF-hand structure in the α-subunit. Analysis of the
primary structure of ClfA indicated the presence of a potential Ca 2+-binding EF-hand-like …
promotes binding of fibrinogen or fibrin to the bacterial cell. Previous studies have shown
that ClfA and the platelet integrin α IIb β 3 recognize the same domain at the extreme C
terminus of the fibrinogen γ-chain. α IIb β 3 interaction with this domain is known to occur in
close proximity to a Ca 2+-binding EF-hand structure in the α-subunit. Analysis of the
primary structure of ClfA indicated the presence of a potential Ca 2+-binding EF-hand-like …