The RING finger domain: a recent example of a sequence—structure family
KLB Borden, PS Freemont - Current opinion in structural biology, 1996 - Elsevier
Current opinion in structural biology, 1996•Elsevier
In the past 18 months, two RING finger structures have been solved. They represent the first
reported structures for this novel zinc-binding sequence motif. Both structures are
significantly different from other zinc-binding domains, in terms of both their zinc-ligation
scheme and their three-dimensional structures. The RING finger domain appears to be a
convenient scaffold which can be altered to provide functional specificity in those proteins
that contain the motif.
reported structures for this novel zinc-binding sequence motif. Both structures are
significantly different from other zinc-binding domains, in terms of both their zinc-ligation
scheme and their three-dimensional structures. The RING finger domain appears to be a
convenient scaffold which can be altered to provide functional specificity in those proteins
that contain the motif.
In the past 18 months, two RING finger structures have been solved. They represent the first reported structures for this novel zinc-binding sequence motif. Both structures are significantly different from other zinc-binding domains, in terms of both their zinc-ligation scheme and their three-dimensional structures. The RING finger domain appears to be a convenient scaffold which can be altered to provide functional specificity in those proteins that contain the motif.
Elsevier