The pathogenic potential of endogenous retroviruses: facts and fantasies
R Löwer - Trends in microbiology, 1999 - cell.com
R Löwer
Trends in microbiology, 1999•cell.comEndogenous retroviruses are descendants of viruses that became cellular genes by
integration into their host's genome. They still contribute to pathogenicity as a partner in
recombination events, by de novo insertion after mobilization followed by activation of
downstream proto-oncogenes, or by gene disruption. Re-expression of viral proteins
accompanied by loss of immune tolerance could induce immune disturbances.
integration into their host's genome. They still contribute to pathogenicity as a partner in
recombination events, by de novo insertion after mobilization followed by activation of
downstream proto-oncogenes, or by gene disruption. Re-expression of viral proteins
accompanied by loss of immune tolerance could induce immune disturbances.
Abstract
Endogenous retroviruses are descendants of viruses that became cellular genes by integration into their host's genome. They still contribute to pathogenicity as a partner in recombination events, by de novo insertion after mobilization followed by activation of downstream proto-oncogenes, or by gene disruption. Re-expression of viral proteins accompanied by loss of immune tolerance could induce immune disturbances.
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