[PDF][PDF] AlaSOPro mutation in the gene encoding α-synuclein in Parkinson's disease

R Krüger, W Kuhn, T Müller, D Woitalla, M Graeber… - Nature …, 1998 - academia.edu
Ckk disease (PD) is characterized by progressive neuronal degeneration which
predominantly affects the dopaminergic neurons in the nigrostriatal system but also several
other regions of the brain". A specific pathological feature of the disease is the presence
ofintracytoplasmic inclusion bodies. These so-called Lewy bodies are found in many brain
regions, including the substantia nigra, locus ceruleus, nucleus basalis, hypothalamus,
cerebral cortex, cranial nerve motor nuclei and the central and peripheral divisions of the …