[HTML][HTML] Synucleins are a novel class of substrates for G protein-coupled receptor kinases
G protein-coupled receptor kinases (GRKs) specifically recognize and phosphorylate the
agonist-occupied form of numerous G protein-coupled receptors (GPCRs), ultimately
resulting in desensitization of receptor signaling. Until recently, GPCRs were considered to
be the only natural substrates for GRKs. However, the recent discovery that GRKs also
phosphorylate tubulin raised the possibility that additional GRK substrates exist and that the
cellular role of GRKs may be much broader than just GPCR regulation. Here we report that …
agonist-occupied form of numerous G protein-coupled receptors (GPCRs), ultimately
resulting in desensitization of receptor signaling. Until recently, GPCRs were considered to
be the only natural substrates for GRKs. However, the recent discovery that GRKs also
phosphorylate tubulin raised the possibility that additional GRK substrates exist and that the
cellular role of GRKs may be much broader than just GPCR regulation. Here we report that …