[HTML][HTML] Dityrosine cross-linking promotes formation of stable α-synuclein polymers: implication of nitrative and oxidative stress in the pathogenesis of …

JM Souza, BI Giasson, Q Chen, VMY Lee… - Journal of Biological …, 2000 - ASBMB
Intracellular proteinaceous aggregates are hallmarks of many common neurodegenerative
disorders, and recent studies have shown that α-synuclein is a major component of several
pathological intracellular inclusions, including Lewy bodies in Parkinson's disease (PD) and
glial cell inclusions in multiple system atrophy. However, the molecular mechanisms
underlying α-synuclein aggregation into filamentous inclusions remain unknown. Since
oxidative and nitrative stresses are potential pathogenic mediators of PD and other …