[HTML][HTML] Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated …
H Yoshida, K Haze, H Yanagi, T Yura, K Mori - Journal of Biological …, 1998 - ASBMB
When unfolded proteins accumulate in the endoplasmic reticulum (ER), transcription of
glucose-regulated proteins (GRPs) representing ER-resident molecular chaperones is
markedly induced via the unfolded protein response (UPR) pathway. In contrast to recent
progress in the analysis of yeast UPR, bothcis-acting elements and transactivators
responsible for mammalian UPR have remained obscure. Here, we analyzed the promoter
regions of human GRP78, GRP94, and calreticulin genes and identified a novel element …
glucose-regulated proteins (GRPs) representing ER-resident molecular chaperones is
markedly induced via the unfolded protein response (UPR) pathway. In contrast to recent
progress in the analysis of yeast UPR, bothcis-acting elements and transactivators
responsible for mammalian UPR have remained obscure. Here, we analyzed the promoter
regions of human GRP78, GRP94, and calreticulin genes and identified a novel element …