Translational regulation in the cellular response to biosynthetic load on the endoplasmic reticulum
HP Harding, I Novoa, A Bertolotti… - Cold Spring Harbor …, 2001 - symposium.cshlp.org
Cold Spring Harbor symposia on quantitative biology, 2001•symposium.cshlp.org
500 HARDING ET AL. sponse to specific signals. Several eIF2α kinases have evolved to
couple specific stress signals to phosphorylation of eIF2α on Ser-51. For example, the
interferon-induced PKR is activated by double-stranded RNA in virally infected cells and
participates in a host adaptation that deprives the invading virus of use of the cell's protein
synthesizing machinery (Kaufman 2000), and HRI, a heme-repressed eIF2α kinase, ensures
the matching of globin biosynthesis in erythroid precursors to the production of the heme …
couple specific stress signals to phosphorylation of eIF2α on Ser-51. For example, the
interferon-induced PKR is activated by double-stranded RNA in virally infected cells and
participates in a host adaptation that deprives the invading virus of use of the cell's protein
synthesizing machinery (Kaufman 2000), and HRI, a heme-repressed eIF2α kinase, ensures
the matching of globin biosynthesis in erythroid precursors to the production of the heme …
500 HARDING ET AL. sponse to specific signals. Several eIF2α kinases have evolved to couple specific stress signals to phosphorylation of eIF2α on Ser-51. For example, the interferon-induced PKR is activated by double-stranded RNA in virally infected cells and participates in a host adaptation that deprives the invading virus of use of the cell’s protein synthesizing machinery (Kaufman 2000), and HRI, a heme-repressed eIF2α kinase, ensures the matching of globin biosynthesis in erythroid precursors to the production of the heme prosthetic group (Chen 2000).
symposium.cshlp.org