[HTML][HTML] Translational regulation of yeast GCN4: a window on factors that control initiator-tRNA binding to the ribosome
AG Hinnebusch - Journal of Biological Chemistry, 1997 - ASBMB
When subjected to starvation, stress, or viral infections, mammalian cells down-regulate
general protein synthesis by phosphorylating the subunit of eukaryotic translation initiation
factor 2 (eIF2) 1 (1). eIF2 functions in translation initiation by delivering charged initiator
tRNAMet (Met-tRNAi Met) in a ternary complex with GTP to the 40 S ribosomal subunit,
forming a 43 S preinitiation complex. In the translation of most mRNAs, the 43 S complex
binds near the capped 5! end, migrates downstream, and upon reaching the first AUG …
general protein synthesis by phosphorylating the subunit of eukaryotic translation initiation
factor 2 (eIF2) 1 (1). eIF2 functions in translation initiation by delivering charged initiator
tRNAMet (Met-tRNAi Met) in a ternary complex with GTP to the 40 S ribosomal subunit,
forming a 43 S preinitiation complex. In the translation of most mRNAs, the 43 S complex
binds near the capped 5! end, migrates downstream, and upon reaching the first AUG …