Mechanism of immune complex trapping by follicular dendritic cells
TK Van den Berg, K Yoshida, CD Dijkstra - An Antigen Depository of the …, 1995 - Springer
TK Van den Berg, K Yoshida, CD Dijkstra
An Antigen Depository of the Immune System: Follicular Dendritic Cells, 1995•SpringerThe follicular dendritic cell (FDC) is a major constituent of the microenvironment of the
lymphoid follicle. FDC have the characteristic and unique property of binding antigens in the
form of antigen-antibody complexes and retaining these complexes, without ingestion, for
long periods of time. The presence of antigen-antibody complexes, also called immune
complexes, on FDC is believed to play a crucial role in the development of B cell memory
and the affinity maturation of the antibody response against T cell-dependent antigens.
lymphoid follicle. FDC have the characteristic and unique property of binding antigens in the
form of antigen-antibody complexes and retaining these complexes, without ingestion, for
long periods of time. The presence of antigen-antibody complexes, also called immune
complexes, on FDC is believed to play a crucial role in the development of B cell memory
and the affinity maturation of the antibody response against T cell-dependent antigens.
Abstract
The follicular dendritic cell (FDC) is a major constituent of the microenvironment of the lymphoid follicle. FDC have the characteristic and unique property of binding antigens in the form of antigen-antibody complexes and retaining these complexes, without ingestion, for long periods of time. The presence of antigen-antibody complexes, also called immune complexes, on FDC is believed to play a crucial role in the development of B cell memory and the affinity maturation of the antibody response against T cell-dependent antigens.
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