Activated mesangial cells produce vascular permeability factor in early-stage mesangial proliferative glomerulonephritis.
K Noguchi, N Yoshikawa, S Ito-Kariya… - Journal of the …, 1998 - journals.lww.com
Vascular permeability factor (VPF), also known as vascular endothelial growth factor
(VEGF), is a multifunctional cytokine involved in angiogenesis, inflammation, and wound
healing. Although VPF/VEGF has been reported to be produced only by glomerular
podocytes in glomeruli, it was found that it is produced by human cultured mesangial cells
(MC). Therefore, immunohistochemical analysis (using indirect immunofluorescence and in
situ hybridization) of VPF/VEGF in normal kidneys (n= 7) and biopsy specimens taken from …
(VEGF), is a multifunctional cytokine involved in angiogenesis, inflammation, and wound
healing. Although VPF/VEGF has been reported to be produced only by glomerular
podocytes in glomeruli, it was found that it is produced by human cultured mesangial cells
(MC). Therefore, immunohistochemical analysis (using indirect immunofluorescence and in
situ hybridization) of VPF/VEGF in normal kidneys (n= 7) and biopsy specimens taken from …