Hypoxic stimulation of vascular endothelial growth factor expression in activated rat hepatic stellate cells

V Ankoma-Sey, Y Wang, Z Dai - Hepatology, 2000 - journals.lww.com
The tissue repair response to hypoxic stimuli during wound healing includes enhanced
production of angiogenic factors, such as vascular endothelial growth factor (VEGF). Hepatic
stellate cells are oxygen-sensing cells, capable of producing VEGF. We hypothesized that
hypoxia-stimulated signaling in activated stellate cells mediate VEGF secretion during liver
injury. The specific aim was to evaluate the effect of hypoxia on the gene expression of
VEGF in HSC-T6 cells, an immortalized rat hepatic stellate cell line, and in rat primary …