[HTML][HTML] The mechanism of insulin resistance caused by HIV protease inhibitor therapy
H Murata, PW Hruz, M Mueckler - Journal of Biological Chemistry, 2000 - ASBMB
Retroviral protease inhibitors used as therapy for HIV-1 infection have been causally
associated with serious metabolic side effects, including peripheral lipodystrophy,
hyperlipidemia, insulin resistance, and in some cases, overt type 2 diabetes. The etiology of
this characteristic clinical syndrome remains unknown. We demonstrate that the HIV
protease inhibitor, indinavir, dramatically inhibits insulin-stimulated glucose uptake in 3T3-
L1 adipocytes in a dose-dependent manner (63% inhibition observed with 100 μm …
associated with serious metabolic side effects, including peripheral lipodystrophy,
hyperlipidemia, insulin resistance, and in some cases, overt type 2 diabetes. The etiology of
this characteristic clinical syndrome remains unknown. We demonstrate that the HIV
protease inhibitor, indinavir, dramatically inhibits insulin-stimulated glucose uptake in 3T3-
L1 adipocytes in a dose-dependent manner (63% inhibition observed with 100 μm …