[HTML][HTML] The serum and glucocorticoid kinase sgk increases the abundance of epithelial sodium channels in the plasma membrane of Xenopus oocytes
DA de la Rosa, P Zhang, A Náray-Fejes-Tóth… - Journal of Biological …, 1999 - ASBMB
The serum-and glucocorticoid-induced kinase (sgk) is a serine and threonine kinase that
stimulates amiloride-sensitive sodium transport in Xenopus oocytes. Because aldosterone
induces phosphorylation on serine/threonine (Ser/Thr) residues in the carboxyl termini of β
and γ subunits of epithelial sodium channels (ENaCs) and causes an increase in thesgk
transcript in mammalian and amphibian renal epithelial cells, it seems likely that sgk
mediates the action of aldosterone to stimulate sodium transport. Experiments were …
stimulates amiloride-sensitive sodium transport in Xenopus oocytes. Because aldosterone
induces phosphorylation on serine/threonine (Ser/Thr) residues in the carboxyl termini of β
and γ subunits of epithelial sodium channels (ENaCs) and causes an increase in thesgk
transcript in mammalian and amphibian renal epithelial cells, it seems likely that sgk
mediates the action of aldosterone to stimulate sodium transport. Experiments were …