[HTML][HTML] Protons activate brain Na+ channel 1 by inducing a conformational change that exposes a residue associated with neurodegeneration
CM Adams, PM Snyder, MP Price, MJ Welsh - Journal of Biological …, 1998 - ASBMB
BNC1 is a mammalian neuronal cation channel in the novel DEG/ENaC ion channel family.
BNC1 channels are transiently activated by extracellular protons and are constitutively
activated by insertion of large residues, such as valine, in place of Gly-430; residue 430 is a
site where analogous mutations in someCaenorhabditis elegans family members cause a
swelling neurodegeneration. Mutation of Gly-430 to a small amino acid, cysteine, neither
generated constitutive currents nor allowed modification of this residue by sulfhydryl-reactive …
BNC1 channels are transiently activated by extracellular protons and are constitutively
activated by insertion of large residues, such as valine, in place of Gly-430; residue 430 is a
site where analogous mutations in someCaenorhabditis elegans family members cause a
swelling neurodegeneration. Mutation of Gly-430 to a small amino acid, cysteine, neither
generated constitutive currents nor allowed modification of this residue by sulfhydryl-reactive …