[HTML][HTML] Molecular and functional characterization of acid-sensing ion channel (ASIC) 1b
EL Bässler, TJ Ngo-Anh, HS Geisler… - Journal of Biological …, 2001 - ASBMB
Acid-sensing ion channels (ASICs) are activated by extracellular protons and are involved in
neurotransmission in the central nervous system, in pain perception, as well as in
mechanotransduction. Six different ASIC subunits have been cloned to date, which are
encoded by four genes (ASIC1-ASIC4). Proton-gated currents have been described in
isolated neurons from sensory ganglia as well as from central nervous system. However, it is
largely unclear which of the cloned ASIC subunits underlie these native proton-gated …
neurotransmission in the central nervous system, in pain perception, as well as in
mechanotransduction. Six different ASIC subunits have been cloned to date, which are
encoded by four genes (ASIC1-ASIC4). Proton-gated currents have been described in
isolated neurons from sensory ganglia as well as from central nervous system. However, it is
largely unclear which of the cloned ASIC subunits underlie these native proton-gated …