[HTML][HTML] A modulatory subunit of acid sensing ion channels in brain and dorsal root ganglion cells

E Lingueglia, JR de Weille, F Bassilana… - Journal of Biological …, 1997 - ASBMB
MDEG1 is a cation channel expressed in brain that belongs to the degenerin/epithelial Na+
channel superfamily. It is activated by the same mutations which cause neurodegeneration
in Caenorhabditis elegans if present in the degenerins DEG-1, MEC-4, and MEC-10.
MDEG1 shares 67% sequence identity with the recently cloned proton-gated cation channel
ASIC (acid sensing ion channel), a new member of the family which is present in brain and
in sensory neurons. We have now identified MDEG1 as a proton-gated channel with …