Studies on in vivo induction of HIV-1 envelope-specific cytotoxic T lymphocytes by synthetic peptides from the V3 loop region of HIV-1 IIIB gp120
PN Nehete, KS Casement, RB Arlinghaus, KJ Sastry - Cellular immunology, 1995 - Elsevier
We have previously reported the induction of MHC class I-restricted, CD8+ cytotoxic T
lymphocytes (CTLs) specific to human immunodeficiency virus type 1 (HIV-1) in mice by a 15-
amino acid peptide (R15K) from the V3 loop in gp120. We now present evidence showing
that CTL activity induced by R15K was stable for 8–10 weeks after a single injection and that
as little as 20 μg peptide was sufficient for efficient CTL induction in vivo. While induction of
CTLs was efficient with R15K emulsified in either complete or incomplete Freund's adjuvant …
lymphocytes (CTLs) specific to human immunodeficiency virus type 1 (HIV-1) in mice by a 15-
amino acid peptide (R15K) from the V3 loop in gp120. We now present evidence showing
that CTL activity induced by R15K was stable for 8–10 weeks after a single injection and that
as little as 20 μg peptide was sufficient for efficient CTL induction in vivo. While induction of
CTLs was efficient with R15K emulsified in either complete or incomplete Freund's adjuvant …