The peripheral benzodiazepine receptors: a review
A Beurdeley-Thomas, L Miccoli, S Oudard… - Journal of neuro …, 2000 - Springer
A Beurdeley-Thomas, L Miccoli, S Oudard, B Dutrillaux, MF Poupon
Journal of neuro-oncology, 2000•SpringerPeripheral benzodiazepine receptors (PBRs) have been identified in various peripheral
tissues as well as in glial cells in the brain. This review describes the tissue and subcellular
distribution of the PBR in mammalian tissues and analyzes its many putative endogenous
ligands. It deals with the pharmacological, structural and molecular characterization of the
PBR, the proteins associated with the receptor (VDAC, ANC, PRAX-1) and their roles in cell
growth and differentiation, cancer, steroid biosynthesis, and other physiological roles.
tissues as well as in glial cells in the brain. This review describes the tissue and subcellular
distribution of the PBR in mammalian tissues and analyzes its many putative endogenous
ligands. It deals with the pharmacological, structural and molecular characterization of the
PBR, the proteins associated with the receptor (VDAC, ANC, PRAX-1) and their roles in cell
growth and differentiation, cancer, steroid biosynthesis, and other physiological roles.
Abstract
Peripheral benzodiazepine receptors (PBRs) have been identified in various peripheral tissues as well as in glial cells in the brain. This review describes the tissue and subcellular distribution of the PBR in mammalian tissues and analyzes its many putative endogenous ligands. It deals with the pharmacological, structural and molecular characterization of the PBR, the proteins associated with the receptor (VDAC, ANC, PRAX-1) and their roles in cell growth and differentiation, cancer, steroid biosynthesis, and other physiological roles.
Springer