The effect of adding iron to mucin on the enhancement of virulence for mice of Salmonella typhi strain TY 2
CJ Powell Jr, CR DeSett, JP Lowenthal… - Journal of biological …, 1980 - Elsevier
Addition of iron to 'sub-standard'lots of 5% gastric mucin resulted in an enhancement of the
virulence of typhoid strain Ty 2 suspended in the mucin preparations. Because each lot of
mucin differs with respect to iron content, different concentrations of added iron are required
to reduce the LD 50 value to an acceptable level. Iron compounds alone, although
effectively increasing the virulence of strain Ty 2, could not be substituted completely for
mucin in typhoid virulence enhancement. The results indicate that certain mucin lots, found …
virulence of typhoid strain Ty 2 suspended in the mucin preparations. Because each lot of
mucin differs with respect to iron content, different concentrations of added iron are required
to reduce the LD 50 value to an acceptable level. Iron compounds alone, although
effectively increasing the virulence of strain Ty 2, could not be substituted completely for
mucin in typhoid virulence enhancement. The results indicate that certain mucin lots, found …