IL-18-induced expression of intercellular adhesion molecule-1 in human monocytes: involvement in IL-12 and IFN-γ production in PBMC

A Yoshida, HK Takahashi, M Nishibori, H Iwagaki… - Cellular …, 2001 - Elsevier
IL-18 time-and concentration-dependently upregulated the expression of intercellular
adhesion molecule-1 (ICAM-1) in a monocyte population in human PBMC as determined by
FACS analysis while the expression of CD11a, CD18, CD29, CD44, and CD62L in
monocytes and that of ICAM-1, CD11a, CD18, CD29, CD44, and CD62L in T cells was not
influenced by IL-18. IL-18 in the same concentration range stimulated the production of IL-
12, TNF-α, and IFN-γ in culture of PBMC; however, IL-18-induced expression of ICAM-1 in …