Prolactin-induced proliferation of Nb2 cells involves tyrosine phosphorylation of the prolactin receptor and its associated tyrosine kinase JAK2.

JJ Lebrun, S Ali, L Sofer, A Ullrich, PA Kelly - Journal of Biological …, 1994 - ASBMB
The interaction of prolactin with its receptor in the Nb2 cell line has been shown to induce
the phosphorylation of cell-associated proteins and mitogenesis. It has been reported
previously that one of these proteins, phosphorylated upon prolactin stimulation, was a
tyrosine kinase. We have identified this kinase as JAK2, and demonstrate its association
with the prolactin receptor. In addition, we show that the prolactin receptor itself becomes
tyrosine phosphorylated upon ligand stimulation in Nb2 cells. These actions are time …