Prolactin concurrently activates src-PLD and JAK/Stat signaling pathways to induce proliferation while promoting differentiation in embryonic astrocytes

D Mangoura, C Pelletiere, S Leung… - International Journal of …, 2000 - Elsevier
In normal development, embryonic astrocytes progress through their cell lineage by
acquiring differentiation, by apoptosis, and by proliferation. In this study, we show that
embryonic astrocytes may maintain and make gains in differentiation as they simultaneously
progress through one cell cycle when induced by prolactin (PRL). Prolactin induced the
majority of astrocytes to incorporate bromodeoxyuridine (BrdU) with a four-fold increase over
controls after 18 h of exposure. Investigating possible mitogenic signaling pathways we …