[HTML][HTML] Prolactin-induced cell proliferation in PC12 cells depends on JNK but not ERK activation

Y Cheng, I Zhizhin, RL Perlman, D Mangoura - Journal of Biological …, 2000 - ASBMB
The effects of pituitary and extrapituitary prolactin include cellular proliferation and
differentiation. PC12 cells was used as a model to delineate respective signaling of
prolactin. Prolactin acted as a mitogen for undifferentiated PC12 cells, as measured by
significant increases in bromodeoxyuridine incorporation and in cell numbers, with an
efficacy equal to epidermal growth factor. Both the long and short form of the prolactin
receptor was expressed, yet only the long isoform was tyrosine-phosphorylated upon …