Acute effects of rat growth hormone (GH), human GH and prolactin on proliferating rat liver cells in vitro: a study of mitotic behaviour and ultrastructural alterations

G Vergani, A Mayerhofer, A Bartke - Tissue and Cell, 1994 - Elsevier
Examination of livers from transgenic mice over expressing human growth hormone (hGH)
revealed numerous alterations including a striking incidence of mitotic figures. The reason
for increased proliferation is unclear, but could be related to effects of hGH, which is also
acting as a lactogen in rodents. In order to identify some of the actions of GH, we have
examined the effects of rat and human GH and rat prolactin on proliferation, as well as on
morphological differentiation of normal rat liver cells in vitro. These cells, isolated from a 20 …