Neurosteroids: beginning of the story
EE Baulieu, P Robel, M Schumacher - International review of neurobiology, 2001 - Elsevier
Neurosteroids are synthetized in the central and the peripheral nervous system, in glial cells,
and also in neurons, from cholesterol or sieroidal precursors imported from peripheral
sources. They include 3β-hydroxy-Δ 5-compounds, such as pregnenolone (PREG) and
dehydroepiandrosterone, their sulfate esters, and compounds known as reduced
metabolites of steroid hormones, such as the tetrahydroderivative of progesterone 3α-
hydroxy-5α-pregnan-20-one. These neurosteroids can act as modulators of neurotransmitter …
and also in neurons, from cholesterol or sieroidal precursors imported from peripheral
sources. They include 3β-hydroxy-Δ 5-compounds, such as pregnenolone (PREG) and
dehydroepiandrosterone, their sulfate esters, and compounds known as reduced
metabolites of steroid hormones, such as the tetrahydroderivative of progesterone 3α-
hydroxy-5α-pregnan-20-one. These neurosteroids can act as modulators of neurotransmitter …