[HTML][HTML] Translocation inhibitors define specificity of protein kinase C isoenzymes in pancreatic β-cells
M Yedovitzky, D Mochly-Rosen, JA Johnson… - Journal of Biological …, 1997 - ASBMB
The protein kinase C (PKC) family consists of 11 isoenzymes. Following activation, each
isoenzyme translocates and binds to a specific receptor for activated Ckinase
(RACK)(Mochly-Rosen, D.(1995) Science 268, 247-251) that provides an anchoring site in
close proximity to the isoenzyme's specific substrate. Pancreatic islet cells contain at least
six PKC isoenzymes (Knutson, KL, and Hoenig, M.(1994) Endocrinology 135, 881-886).
Although PKC activation enhances insulin release, the specific function of each isoenzyme …
isoenzyme translocates and binds to a specific receptor for activated Ckinase
(RACK)(Mochly-Rosen, D.(1995) Science 268, 247-251) that provides an anchoring site in
close proximity to the isoenzyme's specific substrate. Pancreatic islet cells contain at least
six PKC isoenzymes (Knutson, KL, and Hoenig, M.(1994) Endocrinology 135, 881-886).
Although PKC activation enhances insulin release, the specific function of each isoenzyme …