[HTML][HTML] ATP-binding cassette transporter A1 (ABCA1) functions as a cholesterol efflux regulatory protein
ABCA1, an ATP-binding cassette transporter mutated in Tangier disease, promotes cellular
phospholipid and cholesterol efflux by loading free apoA-I with these lipids. This process
involves binding of apoA-I to the cell surface and phospholipid translocation by ABCA1. The
goals of this study were to examine the relationship between ABCA1-mediated lipid efflux
and apolipoprotein binding and to determine whether phospholipid and cholesterol efflux
are coupled. Inhibition of lipid efflux by glybenclamide treatment or by mutation of the ATP …
phospholipid and cholesterol efflux by loading free apoA-I with these lipids. This process
involves binding of apoA-I to the cell surface and phospholipid translocation by ABCA1. The
goals of this study were to examine the relationship between ABCA1-mediated lipid efflux
and apolipoprotein binding and to determine whether phospholipid and cholesterol efflux
are coupled. Inhibition of lipid efflux by glybenclamide treatment or by mutation of the ATP …