[HTML][HTML] Helical apolipoproteins stabilize ATP-binding cassette transporter A1 by protecting it from thiol protease-mediated degradation
R Arakawa, S Yokoyama - Journal of Biological Chemistry, 2002 - ASBMB
ATP-binding cassette transporter (ABC) A1 was increased by apolipoprotein AI without an
increase of its message in THP-1 cells. The pulse label study demonstrated that apoA-I
retarded degradation of ABCA1. Similar changes were demonstrated by apoA-II, but the
effect of high density lipoprotein was almost negligible on the basis of equivalent protein
concentration. Thiol protease inhibitors (leupeptin andN-acetyl-Leu-Leu-norleucinal (ALLN))
increased ABCA1 and slowed its decay in the cells, whereas none of the proteosome …
increase of its message in THP-1 cells. The pulse label study demonstrated that apoA-I
retarded degradation of ABCA1. Similar changes were demonstrated by apoA-II, but the
effect of high density lipoprotein was almost negligible on the basis of equivalent protein
concentration. Thiol protease inhibitors (leupeptin andN-acetyl-Leu-Leu-norleucinal (ALLN))
increased ABCA1 and slowed its decay in the cells, whereas none of the proteosome …