[HTML][HTML] Dual mechanisms of ABCA1 regulation by geranylgeranyl pyrophosphate
X Gan, R Kaplan, JG Menke, K MacNaul… - Journal of Biological …, 2001 - ASBMB
ATP-binding cassette transporter A1 (ABCA1) mediates an active efflux of cholesterol and
phospholipids and is mutated in patients with Tangier disease. Expression of ABCA1 may
be increased by certain oxysterols such as 22 (R)-hydroxycholesterol via activation of the
nuclear hormone receptor liver X receptor (LXR). In searching for potential modulators of
ABCA1 expression, we have studied the effects of various mevalonate metabolites on the
expression of ABCA1 in two human cell lines, THP-1 and Caco-2 cells. Most of the tested …
phospholipids and is mutated in patients with Tangier disease. Expression of ABCA1 may
be increased by certain oxysterols such as 22 (R)-hydroxycholesterol via activation of the
nuclear hormone receptor liver X receptor (LXR). In searching for potential modulators of
ABCA1 expression, we have studied the effects of various mevalonate metabolites on the
expression of ABCA1 in two human cell lines, THP-1 and Caco-2 cells. Most of the tested …