Lipoproteins activate acyl-coenzyme A: cholesterol acyltransferase in macrophages only after cellular cholesterol pools are expanded to a critical threshold level.
X Xu, I Tabas - Journal of Biological Chemistry, 1991 - ASBMB
Activation of acyl-CoA: cholesterol actyltransferase (ACAT) in macrophages by lipoproteins
is a key event in atheroma foam cell formation. To help elucidate the mechanisms whereby
lipoproteins stimulate ACAT, the early cellular events of lipoprotein-induced ACAT
stimulation were studied in mouse peritoneal macrophages. As a function of increasing
lipoprotein-cholesterol influx to the cell during the first few hours of incubation, ACAT activity
was markedly stimulated by beta-very low density lipoprotein (beta-VLDL) and acetyl-low …
is a key event in atheroma foam cell formation. To help elucidate the mechanisms whereby
lipoproteins stimulate ACAT, the early cellular events of lipoprotein-induced ACAT
stimulation were studied in mouse peritoneal macrophages. As a function of increasing
lipoprotein-cholesterol influx to the cell during the first few hours of incubation, ACAT activity
was markedly stimulated by beta-very low density lipoprotein (beta-VLDL) and acetyl-low …