[HTML][HTML] The distal pathway of lipoprotein-induced cholesterol esterification, but not sphingomyelinase-induced cholesterol esterification, is energy-dependent
PJ Skiba, X Zha, FR Maxfield, SL Schissel… - Journal of Biological …, 1996 - ASBMB
The stimulation of the intracellular cholesterol esterification pathway by atherogenic
lipoproteins in macrophages is a key step in the development of atheroma foam cells. The
esterification pathway can also be stimulated by hydrolysis of cell-surface sphingomyelin by
the enzyme sphingomyelinase (SMase). In both cases, intracellular cholesterol transport to
the cholesterol esterifying enzyme, acyl-CoA: cholesterol O-acyltransferase (ACAT), is
thought to be critical, although the mechanism of cholesterol transport is not known. In this …
lipoproteins in macrophages is a key step in the development of atheroma foam cells. The
esterification pathway can also be stimulated by hydrolysis of cell-surface sphingomyelin by
the enzyme sphingomyelinase (SMase). In both cases, intracellular cholesterol transport to
the cholesterol esterifying enzyme, acyl-CoA: cholesterol O-acyltransferase (ACAT), is
thought to be critical, although the mechanism of cholesterol transport is not known. In this …