[PDF][PDF] Ubiquitin enters the new millennium
CM Pickart - Molecular cell, 2001 - cell.com
CM Pickart
Molecular cell, 2001•cell.comMeeting Review Ubiquitin Enters the New Millennium Page 1 Molecular Cell, Vol. 8, 499–504,
September, 2001, Copyright ©2001 by Cell Press Meeting Review Ubiquitin Enters the New
Millennium involves the sequential actions of activating (E1), conjuCecile M. Pickart1 gating
(E2), and ligase (E3) enzymes. The E3 is the princiDepartment of Biochemistry and Molecular
Biology pal substrate recognition factor (Hershko and CiechaBloomberg School of Public
Health nover, 1998) (see Figure 1). A given E3 usually binds its Johns Hopkins University …
September, 2001, Copyright ©2001 by Cell Press Meeting Review Ubiquitin Enters the New
Millennium involves the sequential actions of activating (E1), conjuCecile M. Pickart1 gating
(E2), and ligase (E3) enzymes. The E3 is the princiDepartment of Biochemistry and Molecular
Biology pal substrate recognition factor (Hershko and CiechaBloomberg School of Public
Health nover, 1998) (see Figure 1). A given E3 usually binds its Johns Hopkins University …
Abstract
The latest advances in ubiquitin-mediated signaling were discussed at a recent FASEB meeting in Vermont. New findings show that besides signaling proteolysis, ubiquitination can be a signal for trafficking, kinase activation, and other nonproteolytic fates.
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